The remarkable anticancer properties of dolastatin 10, isolated from the sea hare (sea slug) Dolabella auricularia, have led to interest in closely related derivatives (auristatins) suitable for clinical trials. Most recently, such auristatins have been linked to antibodies for delivery. In many indications, however, it would be desirable to deliver...

Wound healing is one of the most important processes in the body. When the healing process, however, is overly active at the cellular level, fibrosis can occur. This can result in scarring that can obliterate the architecture of the underlying organ or tissue. Smooth muscle cell migration can also occur, likewise promoting scar formation. If the...