Dolastatin compounds, isolated from the sea hare (sea slug) Dolabella auricularia, have been shown to have remarkable anticancer properties. In particular, dolaststin 16 has been shown to be an extraordinarily potent cancer cell growth inhibitor. Its 3-dimensional structure, however, has heretofore remained unknown. Researchers at Arizona State...

The remarkable anticancer properties of dolastatin 10, isolated from the sea hare (sea slug) Dolabella auricularia, have led to interest in closely related derivatives (auristatins) suitable for clinical trials. Most recently, such auristatins have been linked to antibodies for delivery. In many indications, however, it would be desirable to deliver...

Kitasatospora sp. produces a variety of metabolites with anti-cancer activity, such as the cyclodepsipeptide respirantin. Researchers at Arizona State have isolated other related molecules with anti-cancer and anti-microbial activities: kitastatin 1 and a valeryl modification of respirantin. These three compounds exhibit potent anti- cancer cell...

The Combretastatins, discovered by ASU researchers, are a series of very potent antineoplastic compounds. Combretastatin A-4 (CA4), the most potent compound of the family, is currently undergoing phase III human cancer clinical trials. ASU researchers have conducted extended SAR on Combretastatins. They eventually synthesized structural analogs...

Cancer is the second leading cause of death in the United States. The discovery then of new classes of drugs to address this constellation of diseases is critical to mitigating many presently untreatable conditions. One approach to new drug discovery in this area is the systematic investigation of marine organisms. They are potential sources of...

THERAPEUTIC APPLICATIONS Rheumatoid arthritis Possibly other autoimmune diseases, such as, IBD, Crohn’s Disease, Ulcerative Colitis, Atherosclerosis, etc. EFFICACY In the adjuvant induced arthritis model in rats, SNS, dosed orally, reduces dorsoplantar swelling in a dose dependent manner. More significantly, SNS also displays dose...

THERAPEUTIC APPLICATIONS Rheumatoid arthritis Possibly other autoimmune diseases, such as, IBD, Crohn’s Disease, Ulcerative Colitis, Atherosclerosis, etc. EFFICACY In the adjuvant induced arthritis model in rats, SNS, dosed orally, reduces dorsoplantar swelling in a dose dependent manner. More significantly, SNS also displays dose...

The Combretastatins, discovered by ASU researchers, are a series of very potent antineoplastic compounds. Combretastatin A-4 (CA4), the most potent compound of the family, is currently undergoing phase III human cancer clinical trials. ASU researchers have conducted extended SAR on Combretastatins. They eventually synthesized structural analogs...

SODIUM NARCISTATIN (SNS) A Potent, Orally Bioavailable Anti-Inflammatory Compound With Bone Sparing Activity THERAPEUTIC APPLICATIONS Rheumatoid arthritis Possibly other autoimmune diseases, such as, IBD, Crohn’s Disease, Ulcerative Colitis, Atherosclerosis, etc. EFFICACY In the adjuvant induced arthritis model in rats, SNS, dosed...

The early promise of pancratistatin as a new type of anticancer and antiviral drug led to various preclinical developments. While there have been improvements to the availability of pancratistatin by the development of new horticultural and synthetic approaches, still there is a need for more efficient techniques for the conversion of pancratistatin...