Kitasatospora sp. produces a variety of
metabolites with anti-cancer activity, such as the cyclodepsipeptide
respirantin.
Researchers at Arizona State have isolated other related
molecules with anti-cancer and anti-microbial activities: kitastatin 1 and a
valeryl modification of respirantin.
These three compounds exhibit potent anti- cancer cell
growth properties (GI50 ~ 0.0006 µg/mL). These compounds
also have potential anti-infective activities.
Researchers at ASU have also realized the total synthesis of
the respirantin compound. This approach should offer ready access to the
scale-up synthesis of respirantin, kitastatin and a variety of their structural
analogs.
Potential Applications
- Anti-cancer therapeutic agents
- Anti-microbial and anti-fungal
agents
Benefits and Advantages
- Diversity – Discovery of a
whole class of structurally unique and powerful cancer cell growth inhibitors,
which properties have never been reported. Compounds also present potential
anti-microbial/anti-fungal activities.
- Synthesis – These compounds
are synthetically available.
- Efficacy – The new compounds
display an impressive spectrum of activity against a panel of human cancer
cell lines. Kitastatin 1 showed a special selectivity against the pancreas
BXPC-3 human cancer cell line.
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For more information about the inventor(s) and their
research, please see
Dr.
Pettit's departmental webpage
