Kitasatospora sp. produces a variety of metabolites with anti-cancer activity, such as the cyclodepsipeptide respirantin. Researchers at Arizona State have isolated other related molecules with anti-cancer and anti-microbial activities: kitastatin 1 and a valeryl modification of respirantin. These three compounds exhibit potent anti- cancer cell...

Halistatins are highly potent polyether macrolides with anti-mitotic actions that were originally isolated from certain marine sponges. Similar polyether macrolides, such as, Bryostatin 1 (Ph2), Halichondrin B (PC) and its analog, E7389 (Ph 2), are being tested both preclinically and clinically as anti-cancer agents. Halistatin 1 has highly potent...