A single biomarker is often insufficient to identify a given disease with both sensitivity and specificity. In such cases, one or more additional tests for other biomarkers are used in order to accurately diagnose the disease. The disadvantage of this process is that multiple sensors, wells, platforms, and/or labels are frequently required to measure...

THERAPEUTIC APPLICATIONS Rheumatoid arthritis Possibly other autoimmune diseases, such as, IBD, Crohn’s Disease, Ulcerative Colitis, Atherosclerosis, etc. EFFICACY In the adjuvant induced arthritis model in rats, SNS, dosed orally, reduces dorsoplantar swelling in a dose dependent manner. More significantly, SNS also displays dose...

THERAPEUTIC APPLICATIONS Rheumatoid arthritis Possibly other autoimmune diseases, such as, IBD, Crohn’s Disease, Ulcerative Colitis, Atherosclerosis, etc. EFFICACY In the adjuvant induced arthritis model in rats, SNS, dosed orally, reduces dorsoplantar swelling in a dose dependent manner. More significantly, SNS also displays dose...

The Combretastatins, discovered by ASU researchers, are a series of very potent antineoplastic compounds. Combretastatin A-4 (CA4), the most potent compound of the family, is currently undergoing phase III human cancer clinical trials. ASU researchers have conducted extended SAR on Combretastatins. They eventually synthesized structural analogs...

SODIUM NARCISTATIN (SNS) A Potent, Orally Bioavailable Anti-Inflammatory Compound With Bone Sparing Activity THERAPEUTIC APPLICATIONS Rheumatoid arthritis Possibly other autoimmune diseases, such as, IBD, Crohn’s Disease, Ulcerative Colitis, Atherosclerosis, etc. EFFICACY In the adjuvant induced arthritis model in rats, SNS, dosed...

The early promise of pancratistatin as a new type of anticancer and antiviral drug led to various preclinical developments. While there have been improvements to the availability of pancratistatin by the development of new horticultural and synthetic approaches, still there is a need for more efficient techniques for the conversion of pancratistatin...

ASU researchers began to investigate the blue sponge Cribrochalina sp. in 1986. From this species they successively isolated Cribrostatins 1 to 5 compounds. Cribrostatins 3 and 5 disclosed high potency against a minipanel of human cancer cell lines (Mean panel GI50 values of 4.27 x 10-6M and 5.01 x 10-6M respectively) and Cribrostatins 2 and 4 had...

Resveratrol, phenstatin and combretastatin A-4 are molecules belonging to the classes of stilbenes or benzophenones. Resveratrol is known to possesst a variety of useful biological properties, i.e. antileukemic and antibacterial properties, and has displayed cancer cell growth inhibition in vitro. Combretastatin A-4 has anti-mitotic activity and...

In the early 80s the collection of Pancratium found a very potent anticancer constituent, pancratistatin. Subsequently, the U.S. National Cancer Institute initiated preclinical development of pancratistatin due to its high level of in vitro and in vivo cancer cell growth inhibitory. Unfortunately, the preclinical development slowed by severe supply...

The Combretastatin A-4 (CA-4) Prodrug is a very promising compound now in phase II clinical trials against cancer. CA-4 is acting as a tubulin polymerization inhibitor, preventing cancerous cells from dividing. While performing a structural activity relationship (SAR) study of the antineoplastic compound CA-4, ASU researchers discovered the Phenstatins...