The early promise of pancratistatin as a new type of
anticancer and antiviral drug led to various preclinical developments. While
there have been improvements to the availability of pancratistatin by the
development of new horticultural and synthetic approaches, still there is a need
for more efficient techniques for the conversion of pancratistatin to the water
soluble phosphate prodrug.
Researchers at Arizona State University have developed a new
series of promising 3, 4-O cyclic phenpanstatin phosphate prodrugs, 3,4-O cyclic
pancratistatin phosphate prodrugs, and 4-O sodium pancratistatin phosphate
drugs. They have also developed novel methods for synthesizing each of these new
compounds.
The prodrugs exhibit excellent cancer cell inhibitory
activity. This suggests that they could be developed into significant anticancer
drugs. Pancratistatin has also been found to display remarkable activity against
microspirochesis, another potentially lethal challenge for some cancer patients.
Potential Applications
- Phosphate prodrugs
- Anticancer drugs
- Antiviral drugs
Benefits and Advantages
- Can be prepared as a capsule or for injection
- Oral administration could be either solid or
liquid
Download original PDF.
For more information about the inventor(s) and their
research, please see
Dr.
Pettit's departmental webpage
