SODIUM NARCISTATIN (SNS)
A Potent, Orally Bioavailable Anti-Inflammatory Compound
With Bone Sparing Activity
THERAPEUTIC APPLICATIONS
- Rheumatoid arthritis
- Possibly other autoimmune diseases, such as, IBD, Crohn’s
Disease, Ulcerative Colitis, Atherosclerosis, etc.
EFFICACY
- In the adjuvant induced arthritis model in rats, SNS,
dosed orally, reduces dorsoplantar swelling in a dose dependent manner.
- More significantly, SNS also displays dose dependent bone
sparing activity.
- Dose dependent reductions in:
- Joint space narrowing
- Bone erosion
- Osteoporosis
- Periosteal bone formation.
- SNS outperforms both methotrexate and Remicade in
this model.
SAFETY
- SNS displays a benign safety profile in preliminary tox
studies.
- No effects on general health, body weight, serum
chemistries.
- Gross organ exam normal.
MECHANISM OF ACTION
- SNS works early in the inflammatory cascade, hence
inhibiting the action of many downstream cytokines.
OTHER FEATURES
- SNS (& analogs) has solid IP protection.
- SNS synthesis is straightforward and inexpensive.
- SNS is highly water soluble.
- There is scope for more SAR on SNS.
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For more information about the inventor(s) and their
research, please see
Dr.
Pettit's departmental webpage
