ASU researchers began to investigate the blue sponge Cribrochalina sp. in 1986. From this species they successively isolated Cribrostatins 1 to 5 compounds. Cribrostatins 3 and 5 disclosed high potency against a minipanel of human cancer cell lines (Mean panel GI50 values of 4.27 x 10-6M and 5.01 x 10-6M respectively) and Cribrostatins 2 and 4 had...