Protein microarrays have the potential to revolutionize proteomics research for vaccine development, drug discovery, and diagnosis. However, this potential is far from being realized mainly due to technical complexity of protein array fabrication and uncertainties about the functionality and integrity of proteins once immobilized onto a solid surface....

A single biomarker is often insufficient to identify a given disease with both sensitivity and specificity. In such cases, one or more additional tests for other biomarkers are used in order to accurately diagnose the disease. The disadvantage of this process is that multiple sensors, wells, platforms, and/or labels are frequently required to measure...

Despite recent advances in early detection and treatment, breast cancer remains a common and devastating health problem. With the advent of molecularly-targeted therapeutics, biomarkers that are associated with biological subtypes of cancer may be useful for predicting responses to therapeutic interventions. Researchers at the Biodesign Institute...

Loss of bone mineral content leads to a variety of significant medical problems such as osteoporosis. Development of new treatments for metabolic bone disease and evaluation of the effectiveness of existing therapies in individual patients are severely hampered by the lack of a reliable tool for quickly measuring changes in bone mineral balance...