Despite revolutionary advances in genomics and the study of gene expression, the majority of the encoded proteins have functions that are unknown. The next great challenge for biological research is to understand the function of all proteins; this is particularly important because most diseases are the result of protein dysfunction, and nearly all...

Despite recent advances in early detection and treatment, breast cancer remains a common and devastating health problem. With the advent of molecularly-targeted therapeutics, biomarkers that are associated with biological subtypes of cancer may be useful for predicting responses to therapeutic interventions. Researchers at the Biodesign Institute...