Search Results - john+chaput

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  1. Pipeline for the Production of Bivalent Synthetic Antibodies to the Human Proteome
    Despite revolutionary advances in genomics and the study of gene expression, the majority of the encoded proteins have functions that are unknown. The next great challenge for biological research is to understand the function of all proteins; this is particularly important because most diseases are the result of protein dysfunction, and nearly all...
    Published: 7/11/2014
    Inventor(s): John Chaput, Joshua Labaer, Mitch Magee, Ji Qiu
    Keywords(s):  
    Category(s): Life Science
  2. A Method to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation
    Non-classical translation initiation sites are believed to play an important role in the human genome. Studies of these, however, have been limited by the absence of effective tools for identifying their sequences at the DNA level. There is a pressing need then for new functional tools that can be used to identify and map these sequences in known...
    Published: 7/11/2014
    Inventor(s): John Chaput, Sudhir Kumar, Bertram Jacobs
    Keywords(s): Bio-Technology
    Category(s): Bioengineering, Medical & Sensors
  3. Synbodies -- High Throughput Development of Synthetic Antibodies
    The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...
    Published: 7/11/2014
    Inventor(s): Stephen Johnston, Neal Woodbury, Chris Diehnelt, Paul Belcher, Nidhi Gupta, ZhaN-Gong Zhao, Matthew Greving, Jack Emery, Hao Yan, John Chaput
    Keywords(s):  
    Category(s): Life Science
  4. Synbodies -- High Throughput Development of Synthetic Antibodies
    The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...
    Published: 7/11/2014
    Inventor(s): Stephen Johnston, Neal Woodbury, Chris Diehnelt, Paul Belcher, Nidhi Gupta, ZhaN-Gong Zhao, Matthew Greving, Jack Emery, John Chaput, Hao Yan
    Keywords(s):  
    Category(s): Life Science
  5. Nanoarrays for single-cell RNA Expression
    A variety of medical ailments can be characterized by the presence of specific nucleic acids, proteins, and lipids that are generated during the course of the ailment. Multiplexed and sensitive detection of these molecules is of great importance in the medical diagnostics field. Current technologies designed to detect biological events coded by...
    Published: 7/11/2014
    Inventor(s): John Chaput, Hao Yan, Stuart Lindsay, Peiming Zhang
    Keywords(s):  
    Category(s): Life Science
  6. Synbodies -- High Throughput Development of Synthetic Antibodies
    The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...
    Published: 7/11/2014
    Inventor(s): Stephen Johnston, Neal Woodbury, John Chaput, Chris Diehnelt, Hao Yan
    Keywords(s):  
    Category(s): Life Science

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