Norovirus causes almost 90% of epidemic, non-bacterial outbreaks of gastroenteritis around the world. Extremely infectious and diverse, the virus causes acute diarrhea, vomiting, abdominal cramps, headache, fatigue, and fever. Though the illness is generally resolved within 48 hours, mortalities do occur in the young, elderly, and immune-compromised,...

Norovirus causes almost 90% of epidemic, non-bacterial outbreaks of gastroenteritis around the world. Extremely infectious and diverse, the virus causes acute diarrhea, vomiting, abdominal cramps, headache, fatigue, and fever. Though the illness is generally resolved within 48 hours, mortalities do occur in the young, elderly, and immune-compromised,...

The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...

AKT1 is an enzyme associated with a variety of physiological responses including insulin-stimulated protein synthesis, apoptosis inhibition and the mediation of the effects of several growth factors. Importantly, elevated levels of AKTI have been reported in breast, ovarian and pancreatic cancers and are associated with tumorigenesis, tumor invasiveness...

The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...

Two-dimensional microarrays have proven useful for a wide range of applications, from ELISA microarrays to basic protein research. However, attaching an antibody, enzyme, or other protein to a functionalized surface is not without its problems. Antibodies are costly and time-consuming to produce and screen, and the process of attaching a protein...

The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...