The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...

The development of new drugs and diagnostic assays requires the ability to identify and prepare high-affinity, high-specificity ligands. Monoclonal antibodies are useful reagents in this regard, but are difficult to humanize and express in large amounts. Monoclonal antibodies are also intrinsically limited by the immunological repertoire of the...

Microarrays are commonly used in the analysis of an analyte or a mixture of analytes for the purposes of identification and quantification, as well as to characterize their physical and chemical properties. For example, DNA microarrays are often used to identify the presence or amount of specific gene transcripts or other specific nucleic acid sequences....