Homologous recombination is the process by which similar DNA sequences exchange information with one another. Since homologous recombination is a rare event, various selection markers are used for isolation of recombinants that have undergone homo-logous recombination. Though a variety of positive selection markers exists, very few negative selection...

Non-classical translation initiation sites are believed to play an important role in the human genome. Studies of these, however, have been limited by the absence of effective tools for identifying their sequences at the DNA level. There is a pressing need then for new functional tools that can be used to identify and map these sequences in known...

Vaccination is a critical tool in medicine for achieving the immunological protection of a host against a disease. Vaccines typically comprise an antigen and an adjuvant. The former is the target against which the host’s immune response is raised. The latter is an essential booster of that response. Double-stranded RNA (dsRNA) is a potent adjuvant....

Modified vaccinia virus can be used as a vector to deliver genes encoding proteins for therapeutic and vaccine applications. Researchers at the Biodesign Institute of Arizona State University and their collaborators at the Massachusetts Institute of Technology have developed a form of vaccinia virus with genetic modifications that decrease the risk...

Modified vaccinia virus can be used as a vector to deliver genes encoding proteins for therapeutic and vaccine applications. Researchers at the Biodesign Institute of Arizona State University and their collaborators at the Massachusetts Institute of Technology have developed a form of vaccinia virus with genetic modifications that decrease the risk...

Modified vaccinia virus can be used as a vector to deliver genes encoding proteins for therapeutic and vaccine applications. Researchers at the Biodesign Institute of Arizona State University and their collaborators at the Massachusetts Institute of Technology have developed a form of vaccinia virus with genetic modifications that decrease the risk...

Vaccinia Virus Vectors and Methods to Prevent the Pathology Caused by Infectious Agents Modified vaccinia virus can be used as a vector to deliver genes encoding proteins for therapeutic and vaccine applications. Researchers at the Biodesign Institute of Arizona State University and their collaborators at the Massachusetts Institute of Technology...