Physical activity monitoring devices, such as accelerometers, are useful aids to athletes and those exercising to lose weight. However, such devices cannot monitor rest energy expenditures, which is over 75% of daily energy usage. For those seeking to lose weight and especially those who cannot exercise, there is a need for a device that can accurately...

A single biomarker is often insufficient to identify a given disease with both sensitivity and specificity. In such cases, one or more additional tests for other biomarkers are used in order to accurately diagnose the disease. The disadvantage of this process is that multiple sensors, wells, platforms, and/or labels are frequently required to measure...

A major limitation of current methods to detect specific DNA sequences is the need to amplify the target DNA to detectable levels using PCR. The additional instrumentation and reagents required for PCR severely limit the portability of PCR based detection systems, greatly extend the time required for analysis, and potentially introduce significant...

DNA binding proteins play an important regulatory role in activating transcription. Both the study and the utility of such specific DNA binding proteins would be enhanced if the binding protein where able to report its binding state and some information about its environment. In addition, it would be useful if controlled activities, such as DNA...

A major limitation of current methods to detect specific DNA sequences is the need to amplify the target DNA to detectable levels using PCR. The additional instrumentation and reagents required for PCR severely limit the portability of PCR based detection systems, greatly extend the time required for analysis, and potentially introduce significant...