A major limitation of current methods to detect specific DNA sequences is the need to amplify the target DNA to detectable levels using PCR. The additional instrumentation and reagents required for PCR severely limit the portability of PCR based detection systems, greatly extend the time required for analysis, and potentially introduce significant...

DNA binding proteins play an important regulatory role in activating transcription. Both the study and the utility of such specific DNA binding proteins would be enhanced if the binding protein where able to report its binding state and some information about its environment. In addition, it would be useful if controlled activities, such as DNA...

A major limitation of current methods to detect specific DNA sequences is the need to amplify the target DNA to detectable levels using PCR. The additional instrumentation and reagents required for PCR severely limit the portability of PCR based detection systems, greatly extend the time required for analysis, and potentially introduce significant...