Live attenuated vaccines are considered among the most powerful tools for disease control and potentially disease eradication. Although vaccines have made a major contribution to public health, there are still significant deaths from diseases for which vaccines are not available. There is a need to develop better, safer, and cheaper vaccines capable...

Live attenuated vaccines are considered among the most powerful tools for disease control and potentially disease eradication. Although vaccines have made a major contribution to public health, there are still significant deaths from diseases for which vaccines are not available. There is a need to develop better, safer, and cheaper vaccines capable...

Homologous recombination is the process by which similar DNA sequences exchange information with one another. Since homologous recombination is a rare event, various selection markers are used for isolation of recombinants that have undergone homo-logous recombination. Though a variety of positive selection markers exists, very few negative selection...

More than 170 million people worldwide are chronic carriers of Hepatitis C Virus (HCV), but there is no therapeutic vaccine currently available for treating this infection. Persistent HCV infection results in chronic active hepatitis which may lead to progressive liver disease. Current treatment strategies are expensive, have substantial side effects,...