Conventional cancer therapies are limited by a number of factors including the develop-ment of drug-resistant tumor cells, the toxicity of treatment agents to normal tissue, and the difficulty of bringing therapy to poorly perfused areas of solid tumors. While these factors have prompted the development of new approaches for the treatment of cancer,...

DNA immunization strategies offer the promise of controlling avian coccidiosis in the poultry industry. DNA vaccination, however, typically requires delivery of large quantities of DNA by injection or particle gun. This mandates the handling of individual birds for each vaccination and makes the use of DNA vaccines prohibitively expensive for control...

High-level expression of genes encoding protective antigens produced by recombinant attenuated Salmonella vaccine strains is desirable to maximize antibody responses to the protective antigen(s). However, high-level expression of protective antigens that are of no benefit to the recombinant attenuated Salmonella vaccine strain causes the strain...