The FIRST software (Floppy Inclusions and Rigid
Substructure Topography) was developed by researchers at Arizona State
University for analyzing conformations of proteins and other biomolecules.
This software uses patented algorithms for identifying rigid
and flexible regions within proteins and other biomolecules of thousands of
residues in a few seconds.
The FRODA module (Framework Rigidity-Optimized Dynamics
Algorithm) within the FIRST software uses geometric simulation algorithms to
quickly explore the “clash free” conformational space in proteins or other
biomolecules. FRODA is capable of generating thousand of distinct conformations
within minutes on a single-processor computer.
The on-line freeware version is available at:
http:/flexweb.asu.edu.
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