The Gañán-Calvo method for utilizing a “virtual nozzle” to 
produce very small diameter columnar liquid jets is currently the state of the 
art in the field. This method involves passing a gaseous fluid entraining a 
liquid fluid through a capillary tube and out an aperture at the end. The 
gas-dynamic forces exerted by the gaseous fluid provide the “virtual nozzle” 
that reduces the liquid flow diameter well below that of the aperture diameter. 
While the Gañán-Calvo method improves markedly over conventional solid walled 
converging nozzles by offering reduced liquid flow diameters and reduced 
incidence of clogging, it cannot render droplet diameters in the 
micrometer/sub-micrometer range. 
Researchers at Arizona State University have developed an 
improved Gas-Dynamic Virtual Nozzle (“GDVN”) that refines the Gañán-Calvo method 
to produce superior columnar liquid jets. Specifically, the ASU GDVN offers 
significantly smaller capillary, orifice, and droplet dimensions, single-file 
microscopic streams, in situ alignment, and miniaturization. Likewise, the ASU 
GDVN can run the flow through a second capillary before or instead of a 
conventional aperture. The ASU GDVN is particularly useful for applications 
where the liquids of interest are complex aqueous solutions containing 
macromolecules or biospecies due to the increased risks of clogging that result 
when converting these particles to micrometer sizes. 
Potential Applications 
  - Experimentation (e.g. Diagnosis, Analysis, Measurement) 
  
  
- Micro-fluidic Engineering (e.g. Biological, Chemical, 
  Material) 
  
- Industry (e.g. Automobile, Food Production) 
  
- Environment 
  
- Energy 
Benefits and Advantages 
  - Smaller Capillary, Orifice, and Droplet Dimensions – 
  operates at capillary and orifice diameters down to 0.02 mm compared to 0.05 – 
  2 mm and produces micron diameter droplets compared to 10.7 micron droplets 
  
  
- Single-File Microscopic Droplet Stream – generates 
  single-file droplet streams for high levels of precision where competing 
  methods generate sprays 
  
- In Situ Alignment of Capillary and Orifice – seals 
  mechanical or piezoelectric drives within the GDVN assembly that adjust the 
  capillary with respect to the orifice 
  
- Microthread Injection Adaptability – offers ability to 
  inject microthreads via combinations of capillaries or capillaries and 
  apertures to minimize overshoot, turbulence, or back eddying in the flow 
  
  
- Miniaturization – facilitates differential 
  pumping
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