Necrotic enteritis poses a major threat to the current
objective of ‘antibiotic-free’ poultry farming. It causes economic loss due to
high mortality in broilers and, most commonly, it causes a chronic sub-clinical
intestinal mucosal damage, leading to reduced feed efficiency and growth
reduction. There is no vaccine in the market for necrotic enteritis. Necrotic
enteritis can be controlled by the routine application of antibiotics at
sub-therapeutic levels in the feed, a practice currently frowned upon and soon
likely to be banned by federal regulations. The withdrawal of in-feed
antibiotics, however, aggravated C. perfringens infection and necrotic
enteritis. A cost effective vaccine is, therefore, highly desirable.
Professor Roy Curtiss and colleagues from the Biodesign
Institute at Arizona State University have developed a recombinant attenuated
Salmonella vaccine administered by spray or in water or food capable of
preventing chicken infection by a Clostridium perfringens leading to necrotic
enteritis.
Potential Applications
- Cost effective vaccination against Clostridium
perfringens
- Avoids antibiotic administration
- Prevents bacterial outbreaks from Clostridium
perfringens.
Benefits and Advantages
- Robust vaccine
- Easy to administer
- Easy to be transported
- Avoids antibiotic administration
- Prevents disease outbreaks
Download Original PDF
For more information about the inventor(s) and their
research, please see
Dr.
Curtiss' directory webpage
Dr.
Curtiss' departmental webpage
