The bleomycins (BLMs) are well-known antineoplastic agents. They are particularly useful in the treatment of squamous cell carcinomas and malignant lymphomas. The therapeutic effect of bleomycin analogues is believed to result from their selective oxidative cleavage of DNA and possibly RNA. Much of the site-specific cleavage is thought to be effected...

ASU researchers have identified new methods and compositions to directly target therapeutics to tumors while also performing diagnostic imaging. Ultrasound contrast agent materials are combined with glycopeptide-based antibiotics in a unique formulation capable of simultaneous targeting of therapeutics and selective imaging. Traditionally used...