Mitochondrial diseases are a group of disorders caused by dysfunctional mitochondria, often caused by genetics or mutations to the mitochondrial DNA. Mitochondrial defects are damaging, particularly to tissues with high energy demands, such as neural and muscle tissues. Energetic defects have been implicated in forms of movement disorders, cardiomyopathy,...

Mitochondria are intracellular organelles responsible for a number of metabolic transformations and regulatory functions. They produce much of the ATP employed by eukaryotic cells. They are also the major source of free radicals and reactive oxygen species that cause oxidative stress. Mitochondrial defects are damaging, particularly to neural and...

The bleomycins (BLMs) are well-known antineoplastic agents. They are particularly useful in the treatment of squamous cell carcinomas and malignant lymphomas. The therapeutic effect of bleomycin analogues is believed to result from their selective oxidative cleavage of DNA and possibly RNA. Much of the site-specific cleavage is thought to be effected...

ASU researchers have identified new methods and compositions to directly target therapeutics to tumors while also performing diagnostic imaging. Ultrasound contrast agent materials are combined with glycopeptide-based antibiotics in a unique formulation capable of simultaneous targeting of therapeutics and selective imaging. Traditionally used...